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Search Results for " peroxisome proliferator-activated receptor gamma "

Targets Recommended: PPAR

15

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T8780	AMG131 INT-131,AMG-131,CHS 131	PPAR	DNA Damage/DNA Repair; Metabolism
	AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。
T0371	Gliquidone AR-DF 26,格列喹酮,Glurenorm	Potassium Channel	Membrane transporter/Ion channel
	Gliquidone (AR-DF 26) 是一种磺酰脲类的抗糖尿病药物，可用于2型糖尿病的研究。
T69146	Suksdorfin	PPAR	DNA Damage/DNA Repair; Metabolism
	Suksdorfin 具有降血糖作用，可促进脂肪细胞分化并增强脂联素的产生，可激活过氧化物酶体增殖物激活受体 γ （PPARγ），可促进脂肪细胞对胰岛素依赖性葡萄糖的摄取，可用于肥胖相关研究。
T69635	NIP-222
	NIP-222 is a peroxisome proliferator-activated receptor (PPAR)gamma agonist.
T69191	Pemaglitazar
	Pemaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonist, with hypoglycemic activity.
T27324	FK614 FK 614,ATx-08-001,ATx-08001,FK-614
	FK-614 is a selective agonist of peroxisome proliferator-activated receptor gamma. FK-614 improves peripheral glucose utilization while decreases hepatic insulin extraction in alloxan-induced diabetic dogs.
T68000	MK 0533
	Mk-0533是一种选择性过氧化物酶体增殖激活受体γ调节剂，用于治疗2型糖尿病。
T73519	FX-909
	FX-909 是一种共价过氧化物酶体增殖体激活受体 γ (PPARG) 逆激动剂。FX-909 可用于肿瘤的研究。
T79182	PPARγ agonist 8	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARγ agonist8，作为PPARγ的激动剂，能够诱导过氧化物酶体增殖反应元件(PPRE)-萤光素酶活性，其EC50值为0.2 μM。
T61417	PPARγ agonist 7
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].
T61836	Pioglitazone potassium
	Pioglitazone potassium (U 72107) is an orally active and selective agonist of peroxisome proliferator-activated receptor gamma (PPARγ). It demonstrates high affinity binding to the ligand-binding domain of PPARγ, with an EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium has applications in diabetes research [2] [3] [4].
T13483	RP 54275 2-Octadecyl-1H-indole-5-carboxylic acid	Others	Others
	RP 54275 是一种天然存在的脂肪酸衍生物，一种新的降胆固醇化合物。它可以激活过氧化物酶体增殖物激活受体γ（PPARγ）途径，该途径参与脂质代谢、炎症和细胞分化的调节。
T75009	PPARγ/GR modulator 1
	PPARγ/GR modulator 1 是一种口服活性的 PPARγ和糖皮质激素受体 (GR) 的双动激动剂，Ki 值分别为 3.3 和 33.6 μM。PPARγ/GR modulator 1 可用于研究代谢疾病，例如糖尿病。
T79284	IR-251
	IR-251是一种线粒体靶向的近红外荧光探针，通过OATP导向线粒体，诱导肿瘤细胞中线粒体损伤。IR-251抑制PPARγ，从而引发ROS的过量生成，进而抑制β-catenin信号通路及相关细胞周期和转移的下游蛋白，有效抑止肿瘤的增殖和转移。
T65598	Cefminox sodium
	Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most activ...

化合物

Cat.No: T8780

Synonym: INT-131,AMG-131,CHS 131

Target: PPAR

Cat.No: T0371

Synonym: AR-DF 26,格列喹酮,Glurenorm

Target: Potassium Channel

Cat.No: T69146

Target: PPAR

Cat.No: T69635

Cat.No: T69191

Cat.No: T27324

Synonym: FK 614,ATx-08-001,ATx-08001,FK-614

Cat.No: T68000

Cat.No: T73519

PPARγ agonist 8

Cat.No: T79182

Target: PPAR

PPARγ agonist 7

Cat.No: T61417

Pioglitazone potassium

Cat.No: T61836

Cat.No: T13483

Synonym: 2-Octadecyl-1H-indole-5-carboxylic acid

Target: Others

PPARγ/GR modulator 1

Cat.No: T75009

Cat.No: T79284

Cefminox sodium

Cat.No: T65598

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02575	PPAR gamma/PPARG Protein, Human, Recombinant (His & GST) CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,...	Human	Baculovirus Insect Cells
	Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli...
TMPJ-01213	ASXL1 Protein, Human, Recombinant (GST) Putative Polycomb group protein ASXL1,Additional sex combs-l...	Human	E. coli
	Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 t...
TMPJ-00705	BCAS2 Protein, Human, Recombinant (His, T7) BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,Pre-mRNA-...	Human	E. coli
	Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ...

重组蛋白

PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02575

Species: Human

Expression System: Baculovirus Insect Cells

ASXL1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01213

Species: Human

Expression System: E. coli

BCAS2 Protein, Human, Recombinant (His, T7)

Cat.No: TMPJ-00705

Species: Human

Expression System: E. coli

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